Coluracetam Basic Info:
Product name :Coluracetam MKC-231
CAS : 135463-81-9
Molecular Formula : C19H23N3O3
Molecular Weight : 341.40
Boiling Point:634.1°C at 760 mmHg °C
Appearance: white crystalline powder
Specification: 99% by HPLC
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Item |
Specifications |
Results |
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Assay(HPLC) |
98.0%~102.0% |
98.9% |
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Appearance |
Off-white crystalline powder |
Complies |
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Identification |
IR |
Complies |
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Melting point |
156.0~160.0℃ |
157.0~158.0℃ |
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Loss on drying |
≤0.5% |
0.11% |
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Residue on ignition |
≤0.1% |
0.06% |
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Related substance |
≤1.0% |
0.75% |
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Heavy metals |
≤10ppm |
Complies |
What is Coluracetam
Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD).BrainCells Inc is currently out-licensing the drug for this purpose.It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
Coluracetam Benefit:
Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.
Coluracetam Function & Application:
Coluracetam is a nootropic agent of the racetam family. It may have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury. Coluracetam has also been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (pcp), and is considered a potential therapeutic drug for schizophrenia.
The mode of action for coluracetam is still being researched, but initial studies indicate that this nootropic interacts with the process of high affinity choline uptake (HACU). This improves a neuron’s ability to create the neurotransmitter acetylcholine, which is involved with memory formation.
Coluracetam Dosage:
Due to the potency of coluracetam, the dosage is relatively low. Animal research indicates that an oral dose of 300 – 3,000 mcg/kg of bodyweight is useful, which translates to around 3.2-32.7mg overall for a human of 150 lbs. Research for human consumption is scarce, but anecdotal evidence suggests 20mg as a good starting dosage for coluracetam. Sublingual can make the impact of coluracetam far more potent.
Custom clearance service:
1) By Express:
Normally there is no specical need for the recipient to clear the customs. If the customs has an objection,our rich experienced and peofessional group will help you clear the customs. We can guarantee th shipment 100%.
2) By Air and by Sea:
Our company will cooperate with the recipient to provide relevant file and information in the customs clearance procedure.
Delivery Service:
We can ship out within 5 days after you make payment if it have stock at Lab, We always send all order by DHL, UPS, TNT, FedEx, EMS and other courier with door-door service, take 5 – 7 business days to your door!
Packing:
Carton: 1kg, 2kg, 5kg with Foil bag inside, or as customer's requirment;
Drum: 10kg, 15kg, 25kg with food grade PE nag inside.
Delivery:
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Shipping Terms |
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By Express |
By Air |
By sea |
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Suitable for ≤ 50kg
Faster 5-7days
High Cost
Door to Door
Easy Pick Up Goods
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Suitable for ≥ 50kg
Fastest: 1-2 days
High Cost
Airport to Airport
Pick Up Goods by Customer
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Suitable for ≥ 500kg
Fast: 15-30 days
Low Cost
Port to Port
Pick Up Goods by Customer
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Payment:
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Payment terms |
Western Union |
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Moneygram |
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PayPal |
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Wire Transfer |
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Bitcoin |
Q1: Can i get some samples
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What’s your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount
A:Different quantity has different discount.
Q7: How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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